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KMID : 0371320020630020138
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Journal of the Korean Surgical Society
2002 Volume.63 No. 2 p.138 ~ p.145
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The Pattern of β-Catenin Expression in Adenomas and Carcinomas of the Gallbladder
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Moon Jong-Ho
Choi Chang-Soo
Yang Young-Il
Paik Kye-Hyung
Choi Young-Kil
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Abstract
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Purpose: β-catenin is a key regulator of the cadherin- mediated cell adhesion system and also plays a role as a transcription regulating factor. Nuclear expression and mutation of β-catenin have been identified in some benign and
malignant
tumors, and over expression of β-catenin indicates an oncogenic potential. This study was designed to clarify the role of β-catenin in the histogenesis of gallbladder carcinoma.
Methods: In benign hyperplastic lesions, adenomas, and carcinomas of the gallbladder, intracellular expression of β-catenin was investigated by immunohistochemical stainings. Cyclin D1 and Ki-67 were also examined.
Results: All of the hyperplastic lesions showed membranous expression of β-catenin. Adenomas and polypoid carcinomas showed significantly higher incidence of cytoplasmic and nuclear expression of β-catenin than hyperplastic lesions and
infiltrative carcinomas (P＜0.01). Loss of β-catenin expression was frequently noticed in infiltrative and poorly differentiated carcinomas. Nuclear expression of β-catenin in carcinomas had unique pathologic characteristics, including polypoid
growing, well differentiated tubular type, and early stage. Cytoplasmic and nuclear expression of β-catenin showed good correlations with cyclin-D1 expression (P＜0.05). The Ki-67 index was significantly higher in infiltrative carcinomas than in
adenomas or polypoid carcinomas (P＜0.05).
Conclusion: Our results suggest that β-catenin as a molecular marker may play a role in the carcinogenesis of the adenoma-carcinoma sequence of polypoid carcinomas. Infiltrative carcinomas, however, may have different mechanisms.
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KEYWORD
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